University of California, San Diego. Artificial kidney, biological transport phenomena, applications of synthetic membranes in bioengineering.

Research in this program focuses on the study of biological transport phenomena with emphasis on applications used with the artificial kidney. Active research interests include: 1) mass and fluid transport during peritoneal dialysis; 2) mathematical modeling of biological transport phenomena; 3) cell culture systems as models for studying biological transport; 4) fluid dynamics in hemodialyzers; 5) hemodialysis membrane biocompatibility and transport phenomena.

J.K. Leypoldt, L.W. Henderson: "Molecular Charge Influences Transperitoneal Macromolecule Transport," Kidney Int. 43:837-844 (1993).

J.K. Leypoldt, L.W. Henderson: "The Effect of Convection on Bidirectional Peritoneal Solute Transport: Predictions From a Distributed Model," Ann. Biomed. Eng. 20:463-480 (1992).

J.K. Leypoldt, et al.: "Net Ultrafiltration May Not Eliminate Backfiltration During Hemodialysis with Highly Permeable Membranes," Artificial Organs 15:164-170 (1991)