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We have developed a novel system based on our hollow fiber membrane technology which allows for the retrievable delivery of cells and solutes, facilitating studies to investigate the local release of centrally-acting therapeutic substances and the mechanism of action for the delivery of soluble factors from grafted cells. This system has been successfully used to test the effectiveness of small molecular weight therapeutic solutes delivered from cells to ameliorate symptoms in a Parkinsonian model in rodents. This system also allows for investigations of how different cell types may influence tissue remodeling and the resultant host tissue response following mechanical injury, the effects of glial scarring/encapsulation on the diffusive transport properties of therapeutic solutes, and the effects of the cellular reactions on impedance and electrical signal measurements from working recording electrodes.
Recent Publications:
Kim YT, Bridge MJ, Tresco PA, The influence of the foreign body response evoked by fibroblast transplantation on soluble factor diffusion in surrounding brain tissue. J Control Release. 2007 Apr 23;118(3):340-7. Epub 2007 Jan 13. [Link]
Kim YT, Hitchcock R, Broadhead KW, Messina DJ, and PA Tresco, A cell encapsulation device for studying soluble factor release from cells transplanted in the rat brain, J Control Release, 2005 Jan 20;102(1):101-11. [Link] |
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Cell Delivery |
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The Keck Center for Tissue Engineering |
